Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.4
USERS' SCORE
Good
Based on 2 Reviews
8.6
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
15
Total Fat
1.5 g
2%**
Fish Oil Concentrate
1.3 g (1,300 mg)
†
Docosahexaenoic Acid (DHA)
1 g (1,000 mg)
†
Top Medical Research Studies
9
We examined how different doses and durations of omega-3 fatty acids (PUFAs) affect heart failure management. Our study analyzed data from 14 randomized controlled trials, involving nearly 9,100 participants. We found that high doses of omega-3 (2000-4000 mg daily) for at least a year significantly improved heart function, particularly left ventricular ejection fraction and peak oxygen consumption. However, lower doses and shorter durations didn't yield the same benefits, and no increased risk of adverse events was noted. More research is needed to solidify these results.
9
We explored the relationship between fish oil supplements and heart health in over 20,000 individuals with type 2 diabetes. The study found that regular fish oil use and higher levels of DHA, a type of omega-3 fatty acid, were linked to a lower risk of serious complications like heart disease and kidney issues.
Specifically, those with elevated DHA levels experienced significant reductions in the risk of macrovascular and microvascular complications. These positive outcomes were partially attributed to improvements in lipid profiles and inflammation.
This research highlights the potential benefits of incorporating DHA into our diets for better heart health.
Specifically, those with elevated DHA levels experienced significant reductions in the risk of macrovascular and microvascular complications. These positive outcomes were partially attributed to improvements in lipid profiles and inflammation.
This research highlights the potential benefits of incorporating DHA into our diets for better heart health.
9
We examined the connection between omega-3 polyunsaturated fatty acid (PUFA) levels and coronary heart disease (CHD). By analyzing 36 relevant studies, we observed that higher omega-3 levels, including DHA, were linked to a lower risk of developing CHD.
The analysis revealed significant reductions in risk, with particularly strong associations for patients with fatal and non-fatal CHD. Overall, our findings suggest that boosting omega-3 intake could be beneficial for heart health.
The analysis revealed significant reductions in risk, with particularly strong associations for patients with fatal and non-fatal CHD. Overall, our findings suggest that boosting omega-3 intake could be beneficial for heart health.
Most Useful Reviews
8.8
Good for heart health
It has a mild flavour and is beneficial for heart health, inflammation, and lowering cholesterol. The Now brand is reputable and suitable for all ages; I recommend it.
8.8
Boosts brain functions
This wonderful omega has a high concentration of DHA, crucial for both brain and heart health. It improves cognitive functions, attentiveness, and supports memory restoration.
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.4
- All Researches
9
We examined how different doses and durations of omega-3 fatty acids (PUFAs) affect heart failure management. Our study analyzed data from 14 randomized controlled trials, involving nearly 9,100 participants. We found that high doses of omega-3 (2000-4000 mg daily) for at least a year significantly improved heart function, particularly left ventricular ejection fraction and peak oxygen consumption. However, lower doses and shorter durations didn't yield the same benefits, and no increased risk of adverse events was noted. More research is needed to solidify these results.
9
We explored the relationship between fish oil supplements and heart health in over 20,000 individuals with type 2 diabetes. The study found that regular fish oil use and higher levels of DHA, a type of omega-3 fatty acid, were linked to a lower risk of serious complications like heart disease and kidney issues.
Specifically, those with elevated DHA levels experienced significant reductions in the risk of macrovascular and microvascular complications. These positive outcomes were partially attributed to improvements in lipid profiles and inflammation.
This research highlights the potential benefits of incorporating DHA into our diets for better heart health.
Specifically, those with elevated DHA levels experienced significant reductions in the risk of macrovascular and microvascular complications. These positive outcomes were partially attributed to improvements in lipid profiles and inflammation.
This research highlights the potential benefits of incorporating DHA into our diets for better heart health.
9
We examined the connection between omega-3 polyunsaturated fatty acid (PUFA) levels and coronary heart disease (CHD). By analyzing 36 relevant studies, we observed that higher omega-3 levels, including DHA, were linked to a lower risk of developing CHD.
The analysis revealed significant reductions in risk, with particularly strong associations for patients with fatal and non-fatal CHD. Overall, our findings suggest that boosting omega-3 intake could be beneficial for heart health.
The analysis revealed significant reductions in risk, with particularly strong associations for patients with fatal and non-fatal CHD. Overall, our findings suggest that boosting omega-3 intake could be beneficial for heart health.
9
We aimed to understand how docosahexaenoic acid (DHA), a form of omega-3 polyunsaturated fatty acid (PUFA), could benefit patients suffering from heart failure. Our investigation drew on a network meta-analysis that included data from 14 randomized controlled trials, comprising 9,075 participants. This analysis focused particularly on the effects of DHA and other omega-3s on heart health metrics.
The findings revealed that high doses of omega-3 PUFA supplementation, specifically between 2000 to 4000 mg daily for at least one year, significantly improved heart function. We observed notable enhancements in the left ventricular ejection fraction and peak oxygen consumption, crucial indicators of heart performance, when compared to control groups.
Interestingly, lower doses and shorter periods of supplementation did not yield the same positive results. Importantly, we found no significant increase in dropout rates or overall mortality among those taking omega-3 PUFAs compared to those who were not. This suggests that high-dose DHA supplementation can enhance cardiac function without raising safety concerns.
Overall, our research indicates that long-term, high-dose DHA can be a beneficial strategy in managing heart failure. However, we recognize that further well-designed trials with stringent criteria are needed to validate these findings fully.
The findings revealed that high doses of omega-3 PUFA supplementation, specifically between 2000 to 4000 mg daily for at least one year, significantly improved heart function. We observed notable enhancements in the left ventricular ejection fraction and peak oxygen consumption, crucial indicators of heart performance, when compared to control groups.
Interestingly, lower doses and shorter periods of supplementation did not yield the same positive results. Importantly, we found no significant increase in dropout rates or overall mortality among those taking omega-3 PUFAs compared to those who were not. This suggests that high-dose DHA supplementation can enhance cardiac function without raising safety concerns.
Overall, our research indicates that long-term, high-dose DHA can be a beneficial strategy in managing heart failure. However, we recognize that further well-designed trials with stringent criteria are needed to validate these findings fully.
9
We explored how docosahexaenoic acid (DHA), a type of omega-3 fatty acid, might help reduce the risk of heart disease, specifically sudden cardiac death (SCD) and cardiovascular mortality. Our investigation drew on data from ten prospective cohort studies involving over 310,000 participants and covered an average follow-up of nearly nine years.
The results were promising. We observed that higher levels of omega-3 fatty acids, including DHA, in the blood were associated with a lower risk of adverse heart events. Specifically, individuals with elevated levels of DHA displayed a notable reduced risk for both SCD and overall cardiovascular mortality when compared to those with lower levels.
This correlation highlights DHA's potential role in heart health, making it an important focus for anyone looking to improve their cardiovascular wellness. Our findings suggest that increasing DHA intake could serve as a proactive step in protecting against serious heart conditions.
The results were promising. We observed that higher levels of omega-3 fatty acids, including DHA, in the blood were associated with a lower risk of adverse heart events. Specifically, individuals with elevated levels of DHA displayed a notable reduced risk for both SCD and overall cardiovascular mortality when compared to those with lower levels.
This correlation highlights DHA's potential role in heart health, making it an important focus for anyone looking to improve their cardiovascular wellness. Our findings suggest that increasing DHA intake could serve as a proactive step in protecting against serious heart conditions.
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
8.8
Good for heart health
It has a mild flavour and is beneficial for heart health, inflammation, and lowering cholesterol. The Now brand is reputable and suitable for all ages; I recommend it.
8.8
Boosts brain functions
This wonderful omega has a high concentration of DHA, crucial for both brain and heart health. It improves cognitive functions, attentiveness, and supports memory restoration.
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Liepinsh E, Gukalova B, Krims-Davis K, Kuka J, Leduskrasta A, et al. EPA and DHA acylcarnitines are less cardiotoxic than are saturated and monounsaturated long-chain acylcarnitines. Biofactors. 2025;51:e70014. doi:10.1002/biof.70014
- Grytten E, Laupsa-Borge J, Cetin K, Bohov P, Nordrehaug JE, et al. Inflammatory markers after supplementation with marine n-3 or plant n-6 PUFAs: A randomized double-blind crossover study. J Lipid Res. 2025;66:100770. doi:10.1016/j.jlr.2025.100770
- Tseng PT, Zeng BY, Hsu CW, Liang CS, Stubbs B, et al. The Optimal Dosage and Duration of ω-3 PUFA Supplementation in Heart Failure Management: Evidence from a Network Meta-Analysis. Adv Nutr. 2025;16:100366. doi:10.1016/j.advnut.2025.100366
- Lee YQ, Tan KH, Chong MF. Biomarkers of PUFA and cardiovascular risk factors and events in healthy Asian populations: a systematic review. Br J Nutr. 2024;132:1474. doi:10.1017/S0007114524002708
- Shi F, Chowdhury R, Sofianopoulou E, Koulman A, Sun L, et al. Association of circulating fatty acids with cardiovascular disease risk: analysis of individual-level data in three large prospective cohorts and updated meta-analysis. Eur J Prev Cardiol. 2025;32:233. doi:10.1093/eurjpc/zwae315
- Tian S, Guo T, Qian F, Qiu Z, Lu Q, et al. Fish Oil, Plasma n-3 PUFAs, and Risk of Macro- and Microvascular Complications among Individuals with Type 2 Diabetes. J Clin Endocrinol Metab. 2024. doi:10.1210/clinem/dgae482
- Xiao Y, Chen Y, Pietzner A, Elbelt U, Fan Z, et al. Circulating Omega-3 Polyunsaturated Fatty Acids Levels in Coronary Heart Disease: Pooled Analysis of 36 Observational Studies. Nutrients. 2024;16. doi:10.3390/nu16111610
- Asbeutah AA, Daher R, Malik A, Hariri E, Alfaddagh A, et al. The Effect of Eicosapentaenoic and Docosahexaenoic Acid Supplementation on Coronary Artery Calcium Progression in Subjects With Diabetes and Coronary Artery Disease: A Secondary Analysis of a Randomized Trial. Am J Cardiol. 2024;225:98. doi:10.1016/j.amjcard.2024.06.001
- Lin ZH, Xiang HQ, Yu YW, Xue YJ, Wu C, et al. Dihydroartemisinin alleviates doxorubicin-induced cardiotoxicity and ferroptosis by activating Nrf2 and regulating autophagy. FASEB J. 2024;38:e23677. doi:10.1096/fj.202400222RR
- Koh HB, Kim HW, Joo YS, Jung CY, Kim HJ, et al. Plasma Levels of Polyunsaturated Fatty Acids and Adverse Kidney Outcomes. Am J Kidney Dis. 2024;84:179. doi:10.1053/j.ajkd.2023.12.020
- Zeinalabedini M, Ladaninezhad M, Mobarakeh KA, Hoshiar-Rad A, Shekari S, et al. Association of dietary fats with ischemic heart disease (IHD): a case-control study. J Health Popul Nutr. 2024;43:19. doi:10.1186/s41043-023-00489-w
- Reiner MF, Bertschi DA, Werlen L, Wiencierz A, Aeschbacher S, et al. Omega-3 Fatty Acids and Markers of Thrombosis in Patients with Atrial Fibrillation. Nutrients. 2024;16. doi:10.3390/nu16020178
- Tang X, Lv X, Wang R, Li X, Xu W, et al. Association of marine PUFAs intakes with cardiovascular disease, all-cause mortality, and cardiovascular mortality in American adult male patients with dyslipidemia: the U.S. National Health and Nutrition Examination Survey, 2001 to 2016. Nutr J. 2023;22:48. doi:10.1186/s12937-023-00873-6
- Nakao K, Noguchi T, Miura H, Asaumi Y, Morita Y, et al. Effect of Eicosapentaenoic Acid/Docosahexaenoic Acid on Coronary High-Intensity Plaques Detected Using Noncontrast T1-weighted Imaging: The AQUAMARINE EPA/DHA Randomized Study. J Atheroscler Thromb. 2024;31:122. doi:10.5551/jat.64063
- Zhong N, Han P, Wang Y, Zheng C. Associations of polyunsaturated fatty acids with cardiovascular disease and mortality: a study of NHANES database in 2003-2018. BMC Endocr Disord. 2023;23:185. doi:10.1186/s12902-023-01412-4
- Ward NC, Ying Q, Chan DC, Pang J, Mori TA, et al. Improved arterial inflammation with high dose omega-3 fatty acids in patients with elevated lipoprotein(a): Selective effect of eicosapentaenoic acid?. J Clin Lipidol. 2023;17:694. doi:10.1016/j.jacl.2023.08.004
- Hamaya R, Cook NR, Sesso HD, Buring JE, Manson JE. A Bayesian Analysis of the VITAL Trial: Effects of Omega-3 Fatty Acid Supplementation on Cardiovascular Events. Am J Clin Nutr. 2025. doi:10.1016/j.ajcnut.2025.02.028
- Tseng PT, Zeng BY, Hsu CW, Liang CS, Stubbs B, et al. The Optimal Dosage and Duration of ω-3 PUFA Supplementation in Heart Failure Management: Evidence from a Network Meta-Analysis. Adv Nutr. 2025;16:100366. doi:10.1016/j.advnut.2025.100366
- Kim JY, Kong SYJ, Jung E, Cho YS. Omega-3 Fatty Acids as Potential Predictors of Sudden Cardiac Death and Cardiovascular Mortality: A Systematic Review and Meta-Analysis. J Clin Med. 2024;14. doi:10.3390/jcm14010026
- O'Keefe EL, O'Keefe JH, Abuissa H, Metzinger M, Murray E, et al. Omega-3 and Risk of atrial fibrillation: Vagally-mediated double-edged sword. Prog Cardiovasc Dis. 2024. doi:10.1016/j.pcad.2024.11.003
- Choi GY, Calder PC. The differential effects of eicosapentaenoic acid and docosahexaenoic acid on cardiovascular risk factors: an updated systematic review of randomized controlled trials. Front Nutr. 2024;11:1423228. doi:10.3389/fnut.2024.1423228
- Shi F, Chowdhury R, Sofianopoulou E, Koulman A, Sun L, et al. Association of circulating fatty acids with cardiovascular disease risk: analysis of individual-level data in three large prospective cohorts and updated meta-analysis. Eur J Prev Cardiol. 2025;32:233. doi:10.1093/eurjpc/zwae315
- Amangurbanova M, Daher R, Asbeutah AA, Vemuri B, Mirza H, et al. Higher epicardial adipose tissue volume is associated with higher coronary fatty plaque volume and is regulated by waist circumference but not EPA+DHA supplementation. J Clin Lipidol. 2024;18:e773. doi:10.1016/j.jacl.2024.06.006
- Lv L, Guo Y, Zheng Z, Li B. Blood metabolites mediate effects of breakfast skipping on heart failure via Mendelian randomization analysis. Sci Rep. 2024;14:18957. doi:10.1038/s41598-024-69874-7
- Wang Y, Yang B, Wang C. The association between fatty acids and atherosclerotic diseases: A mendelian randomization study. Clin Nutr ESPEN. 2024;63:447. doi:10.1016/j.clnesp.2024.06.018
- Tian S, Guo T, Qian F, Qiu Z, Lu Q, et al. Fish Oil, Plasma n-3 PUFAs, and Risk of Macro- and Microvascular Complications among Individuals with Type 2 Diabetes. J Clin Endocrinol Metab. 2024. doi:10.1210/clinem/dgae482
- Asbeutah AA, Daher R, Malik A, Hariri E, Alfaddagh A, et al. The Effect of Eicosapentaenoic and Docosahexaenoic Acid Supplementation on Coronary Artery Calcium Progression in Subjects With Diabetes and Coronary Artery Disease: A Secondary Analysis of a Randomized Trial. Am J Cardiol. 2024;225:98. doi:10.1016/j.amjcard.2024.06.001
- Dinu M, Sofi F, Lotti S, Colombini B, Mattioli AV, et al. Effects of omega-3 fatty acids on coronary revascularization and cardiovascular events: a meta-analysis. Eur J Prev Cardiol. 2024;31:1863. doi:10.1093/eurjpc/zwae184
- Braun TS, Drobner T, Kipp K, Kiehntopf M, Schlattmann P, et al. Validation of Nutritional Approaches to Modulate Cardiovascular and Diabetic Risk Factors in Patients with Hypertriglyceridemia or Prediabetes-The MoKaRi II Randomized Controlled Study. Nutrients. 2024;16. doi:10.3390/nu16091261
- O'Keefe EL, O'Keefe JH, Tintle NL, Westra J, Albuisson L, et al. Circulating Docosahexaenoic Acid and Risk of All-Cause and Cause-Specific Mortality. Mayo Clin Proc. 2024;99:534. doi:10.1016/j.mayocp.2023.11.026
- Zeinalabedini M, Ladaninezhad M, Mobarakeh KA, Hoshiar-Rad A, Shekari S, et al. Association of dietary fats with ischemic heart disease (IHD): a case-control study. J Health Popul Nutr. 2024;43:19. doi:10.1186/s41043-023-00489-w
- Rennemo J, Berge K, Yousaf MN, Eriksen TB, Welde E, et al. An Atypical Course of Cardiomyopathy Syndrome (CMS) in Farmed Atlantic Salmon () Fed a Clinical Nutrition Diet. Microorganisms. 2023;12. doi:10.3390/microorganisms12010026
